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Graft-versus-host disease and disease relapse are the 2 major causes of
failure of allogeneic hematopoietic stem cell transplantation (SCT). Ideally,
patients who undergo transplantation for malignancies would receive the minimum
effective acute graft-versus-host disease (GVHD) prophylaxis to maximize the
graft-versus-tumor potential of the allogeneic SCT.
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