Janet Rowley is being honored for her groundbreaking contributions to the 
understanding of how chromosomes can exchange genetic material, resulting in 
the uncontrolled growth of cells that characterizes cancer. She discovered the 
first such "translocation" in early 1972, while sorting through photographs of 
chromosomes from a patient with acute myelogenous leukemia. In this case, she 
observed that chromosome 8 appeared to trade genetic material with chromosome 
21; part of 21 had broken off and moved to chromosome 8, and part of 8 had 
moved to 21. 

Later that same year, she discovered that another defect linked to chronic 
myelogenous leukemia (CML), known as the Philadelphia chromosome, also resulted 
from a translocation between chromosomes 9 and 22. 

http://cmlsupport.blogspot.com/2005/03/elizabeth-blackburn-and-janet-rowley.html

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