|
PBT-3 is one of a family of stable chemical analogs of the hepoxilins,
products derived from arachidonic acid. We previously showed that PBT-3 caused
apoptosis in the chronic myelogenous leukemia (CML) cell line K-562 in vitro
(Anti-cancer Res 23: 3617-3622, 2003). It was as effective as Gleevec, a novel
agent that blocks tyrosine kinase activity during treatment of CML. We describe,
herein, the growth inhibiting effects of PBT-3 in nude mice into which K-562
cells were transplanted subcutaneously. Groups of mice were treated with vehicle
as control, or PBT-3, or Gleevec. PBT-3 was effective during the 8-day treatment
protocol in inhibiting the growth of the tumours in vivo as was Gleevec.
New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links
|
