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Thrombotic thrombocytopenic purpura (TTP), characterized by
thrombocytopenia and microangiopathic hemolytic anemia, is a relatively rare
disorder. The majority of cases have no defined causes. TTP has been reported in
association with many drugs, but not with imatinib mesylate. We report a
22-year-old African-American woman who developed idiopathic hypereosinophilic
syndrome. She was treated with imatinib mesylate and subsequently developed
microangiopathic hemolytic anemia, thrombocytopenia, and acute renal
failure.
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