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The chronic myeloproliferative diseases, Polycythemia Vera (PV), Essential
Thrombocythemia (ET), Idiopathic Myelofibrosis (IMF) and Chronic Myelogenous
Leukemia (CML) represent a spectrum of pathogenetically related disorders of
varying clinical manifestations. While the origin of CML has been traced to a
dysregulated protein kinase, the product of the bcr/abl oncogene, the molecular
basis of PV, ET and IMF, which as a group share more similarities with each
other than with CML, has been more recalcitrant to solution. However, a major
insight into the molecular basis for the enhanced myeloproliferation and clonal
dominance that characterizes these disorders is now upon us; four groups of
investigators have recently reported that a single, somatic mutation in the
protein tyrosine kinase JAK2 appears responsible for many of the features of PV,
ET and IMF, an observation that promises to impact the diagnosis and treatment
of patients with these disorders, and to spur additional research into the
origins of dysregulated cell growth and function.
New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links
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