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Imatinib (STI571) is a 2-phenylaminopyrimidine derivative used mostly in
the treatment of chronic myeloid leukaemia. It targets the BCR/ABL oncogenic
tyrosine kinase, inhibiting its activity. Using the alkaline comet assay we
showed that STI571 at concentrations ranging from 0.2 to 2muM induced DNA damage
in human leukemic K562 and BV173 cells expressing the BCR/ABL oncogene, whereas
it had no effect in normal human lymphocytes and leukemic CCRF-CEM cells without
the _expression_ of BCR/ABL.
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