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Concurrent medications:
Although certain medicines
should not be used together at all, in other cases two different medicines may
be used together even if an interaction might occur. In these cases, your doctor
may want to change the dose, or other precautions may be necessary. When you are
taking imatinib, it is especially important that your doctor and pharmacist know
if you are taking any of the following:
- Amphotericin B by injection (e.g., Fungizone) or
- Antineoplastics (cancer medicines) or
- Antithyroid agents (medicine for overactive thyroid) or
- Azathioprine (e.g., Imuran) or
- Chloramphenicol (e.g., Chloromycetin) or
- Colchicine or
- Cyclophosphamide (e.g., Cytoxan) or
- Flucytosine (e.g., Ancobon) or
- Ganciclovir (e.g., Cytovene) or
- Interferon (e.g., Intron A, Roferon-A) or
- Mercaptopurine (e.g., Purinethol) or
- Methotrexate (e.g., Rheumatrex) or
- Plicamycin (e.g., Mithracin) or
- Zidovudine (e.g., AZT, Retrovir)Concurrent use of these medicines with
imatinib increases the risk of infection.
- If you have ever been treated with x-rays or other cancer
medicinesImatinib may increase the effects of these medicines or radiation
therapy on the blood.
- Carbamazepine (e.g., Tegretol) or
- Dexamethasone (e.g., Decadron) or
- Phenobarbital (e.g., Luminal) or
- Phenytoin (e.g., Dilantin) or
- Rifampicin (e.g., Rifampin) or
- St. Johns WortThese medications may decrease the amount of imatinib in
your body.
- Clarithromycin (e.g., Biaxin) or
- Erythromycin (e.g., E-Mycin, Erythrocin) or
- Itraconazole (e.g., Sporanox) or
- Ketoconazole (e.g., Nizoral)These medications may increase the amount of
imatinib in your body.
- Cyclosporine (e.g., Sandimmune) or
- Pimozide (e.g., Orap)Imatinib may increase the amount of these medications
in your blood to possibly harmful levels.
- Warfarin (e.g., Coumadin)Imatinib may interfere with the metabolism of
warfarin, which can cause clotting problems.
- Grapefruit or
- Grapefruit juice or
- Grapefruit-containing food or vitaminThese foods or vitamins may increase
the amount of imatinib in your body. This may increase the chance of side
effects.
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