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A new experimental drug may be effective against a certain form of
leukemia resistant to current treatments, research at UT Southwestern Medical
Center shows...The Blood study shows that PD166326 is nearly 100 times more
potent than the current drug imatinib (Gleevec) against cells expressing this
enzyme, Dr. Ilaria said...When mice received a single
oral dose of PD166326, the mutated enzyme activity was rapidly
inhibited, and the white blood count significantly decreased.
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