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Denbinobin (5-hydroxy-3,7-dimethoxy-1,4-phenanthraquinone) has been
reported to exhibit anti-tumor and anti-inflammatory activity. Nevertheless, the
anti-tumor mechanism of denbinobin remains unclear. In the present study, we
evaluated the anticancer activity of denbinobin in human myelogenous K562
leukemia cells. In accordance with the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl
tetrazolium bromide (MTT) assay, we demonstrated that denbinobin inhibited cell
viability in a concentration-dependent manner with an IC(50) value of
1.84muM.
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