---------- Forwarded message ----------

Genetic alterations related to a group of leukemias
Jos� Luis Vizmanos, a lecturer at the University of Navarra, is to
investigate BCR-ABL-negative chronic myeloproliferative syndromes in a
project to last for three years.

According to the scientist, these syndromes make up a heterogeneous group of
leukemias that are difficult to diagnose and to treat given that they show
similar clinical characteristics and have unknown causes.

Nevertheless, it is said that, amongst some patients, gene alteration has
been observed that results in proteins which have an activity known as
tyrosine kinase. Besides its considerable diagnostic importance, the
presence of these lesions present a rational basis for the development and
application of new therapies aimed specifically at this kind of alteration
and which have fewer side effects than conventional treatments.

Jos� Luis Vizmanos underlined that this study is looking for new lesions in
genes with tyrosine kinase activity, with the aim of throwing light on the
involvement of this anomalous activity in these illnesses.

Notes

Internet reference
www.unav.es


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