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Myelodysplastic syndromes (MDS) are a set of oligoclonal disorders of
hematopoietic stem cells characterized by ineffective hematopoiesis that
manifest clinically as anemia, neutropenia, and/or thrombocytopenia of variable
severity. The result often is transfusion-dependent anemia, an increased risk of
infection or hemorrhage, and a potential to progress to acute myelogenous
leukemia (AML). Although progression to acute leukemia can lead to death in
patients with MDS, many deaths are consequences of cytopenias and marrow failure
in the absence of transformation.
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