Hi Group,

I have a question that I would like to pose to the group.  I'd really 
appreciate your answers, both to the group, so that we can all 
benefit from the information, and to me directly.

I was diagnosed in Aug. 04 and began 800mg Gleevec in Sept. 
04.  By Dec. 04, I was in CCR and by March 05, I had reached 
PCRU. I have experienced most of the typical Gleevec side 
effects such as edema, diahrrea, teary eyes, etc, etc.  But I 
believe I am also experiencing another Gleevec side effect that 
the doctors tell me has NOT been reported as a Gleevec side 
effect.

I have noticed that many of my lymph nodes began swelling after 
I started Gleevec therapy.  I have several in the back of my neck 
and in my breasts and under my arms that have enlarged.  I had 
one lymph node in my breast removed and biopsied recently and 
it came back benign (praise G_d), though the surgeon remarked 
to me that when he removed it, it did feel hard (ie- cancerous).  
Now, a week or so ago, I had another ultrasound (just a follow 
up after the surgery) and have learned that one of the lymph 
nodes under my arm has increased from 1.8cm to 2.6cm over a 
three month period.  The surgeon (and Dr. Cortes) believes that I 
need to have it biopsied also.  Dr. Cortes has also suggested 
that cultures be done to check for infections such as 
tuberculosis, fungus and other things, to try to determine what is 
causing the enlarged lymph nodes.

Again, my point here is that I feel the enlarged lymph nodes are 
possibly a side effect of the Gleevec. (Mabey I am correct, mabey 
I'm not.)  The question I am posing to the group is:  "Is there 
anyone else out there that is taking Gleevec that has 
experienced enlarged lymph nodes??"  If so, what have your 
doctors said about it, if anything?

I would really appreciate your input.

Thanks so much.

Libby
Mobile, AL






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