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Pterostilbene and 3,5-hydroxypterostilbene are the natural 3,5-dimethoxy
analogs of trans-resveratrol and piceatannol, two compounds which can induce
apoptosis in tumor cells. In previous studies we demonstrated the importance of
a 3,5-dimethoxy motif in conferring pro-apoptotic activity to stilbene based
compounds so we now wanted to evaluate the ability of pterostilbene and
3,5-hydroxypterostilbene in inducing apoptosis in sensitive and resistant
leukemia cells. When tested in sensitive cell lines, HL60 and HUT78,
3'-hydroxypterostilbene was 50-97 times more potent than trans-resveratrol in
inducing apoptosis, while pterostilbene appeared barely active.
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