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A 26-year-old man with idiopathic hypereosinophilic syndrome (HES) was
treated with imatinib mesylate following a 5-year history of prednisolone
therapy. The patient had hypereosinophilia (absolute eosinophil counts
>1500/3L) occurring in cyclic oscillations as well as histologically
diagnosed eosinophilic vasculitis, bursitis, and periodic soft-tissue swellings.
Laboratory data revealed high levels of serum tryptase and increased numbers of
mast cells in the bone marrow, but serum interleukin 5 levels were within the
normal range. The disease initially responded well to 100 mg/day of imatinib
mesylate but recurred 8 weeks later.
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