---------- Forwarded message ----------

Breakpoints of variant 9;22  translocations in chronic myeloid leukemia
locate preferentially in the  CG-richest regions of the genome -- Genes,
Chromosomes and Cancer

>From 5% to 10% of 9;22 translocations in chronic myeloid  leukemia (CML) are
reported to occur in variant form, that is, with the  involvement of other
regions of the genome in 3-way or more rearrangements. The  literature indicates
that the alternative breakpoints are not distributed  randomly in the genome
but show hotspots. We present data on 289 unpublished  cases of CML with
variant 9;22 translocations having a total of 342 variant 
breakpoints, the largest
independent series to date

_http://www.mdlinx.com/hemeonclinx/thearts.cfm?artid=1224315&specid=17&ok=yes_

(http://www.mdlinx.com/hemeonclinx/thearts.cfm?artid=1224315&specid=17&ok=yes)


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