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The K562 cell line derived from a chronic myelogenous leukemia (CML)
patient exhibits ATP-dependent exclusion of the multidrug resistance (MDR)-type
drugs. The protein tyrosine kinases inhibitors, imatinib mesylate and AG957
allowed for increased doxorubicin and calcein-AM accumulation in these cells.
Maximal modulation was achieved at 3 and 10muM imatinib and AG957, respectively.
This imatinib concentration is comparable to the plasma steady state levels
observed in patients.
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