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Chronic myelogenous leukaemia (CML) is a disorder of the haematopoietic
stem cell that results in malignant expansion of myeloid cells with a
cytogenetic abnormality, and translocation between chromosomes 9 and 22, known
as the Philadelphia chromosome. It has been hypothesized that genetic factors
other than histocompatibility disparity may play a role in predisposition to
developing CML. In this regard, T helper types 1 and 2 (Th1 and Th2) cytokines
and their gene polymorphism seem to be important. Overall _expression_ and
secretion of cytokines are dependent, at least in part, on genetic polymorphism
(nucleotide variations) within the promoter region or other regulatory sequences
of cytokine genes.
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