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_expression_ of BCR-ABL is the leading cause of chronic myelogenous leukemia
(CML). In CML cells, c-Abl _expression_ is silenced by promoter methylation. In
addition, the level of c-Abl needs to be tightly and constantly regulated due to
its cytotoxicity and its rapid degradation after activation. Yet the regulation
of c-Abl _expression_ remains unclear. In an effort to gain better understanding
of c-Abl function, we performed a GST-Abl pull-down screen and identified
TopBP1, a topoisomerase II-binding protein that contains Brca1 carboxyl-terminal
motifs (BRCT) and has been implicated in DNA damage response.
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