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Aging Stem Cells Linked to Leukemia in Elderly

HealthDay

06-22-05

TUESDAY, June 21 (HealthDay News) -- Aging stem cells may be behind an
increased risk of infection and leukemia in older people, according to a
Stanford University School of Medicine study.

The report appears in this week's issue of the Proceedings of the National
Academy of Sciences.

The Stanford team found that in older mice, bone marrow stem cells that
create new blood cells produce fewer immune cells. That means the bodies of
older mice are less able to fight infection.

As well as producing fewer immune cells, the aging blood-forming stem cells
use genes known to be involved in leukemia -- cancers that affect blood
cells. This may be one reason why older people have an increased risk of
developing certain kinds of leukemia, the study authors said.

The findings provide more evidence that aging stem cells or stem cells
responding to conditions in an aging body may be the source of a number of
age-related health problems.

"Aging results in a diminished capacity of the body to maintain tissue and
organ function. Since we know the cells mediating this maintenance are stem
cells, it doesn't take a great leap of faith to think that stem cells are at
the heart of that failure," study co-author and postdoctoral scholar Derrick
Rossi said in a prepared statement.

The researchers said this finding could lead to ways to improve immune
function or prevent leukemia in older people.

More information

The Alliance for Aging Research has more about aging.

For the latest health news & Health-Life Services like tools, calculators, &
a physician locator, go to www.healthday.com.


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