---------- Forwarded message ----------


Platelet transfusions carry risk of infection

Despite the fact that a blood infection called bacterial sepsis is one of
the most frequent causes of death in people who have received platelet
transfusions, most infectious-disease specialists are not aware of recent
standards requiring bacterial testing for contamination of platelets,
according to a new report.

Unlike other blood components that are stored in the cold, platelets are
particularly vulnerable to bacterial growth because they are stored at room
temperature.

Writing in the US Centers for Disease Control and Prevention's Morbidity and
Mortality Weekly Report (MMWR), Dr. A. Arendt, with the Cuyahoga County
Board of Health in Ohio, and associates describe two case reports of
patients who died after receiving pooled platelets contaminated with the
bacteria Staphylococcus aureus and S. lugdunensis.

They also report results of surveys sent out by the Infectious Diseases
Society of America to infectious- disease consultants in the US. Among the
399 respondents, 36% reported they were unaware that "bacterial
contamination of platelets is one of the most common infectious risks of
transfusion therapy."

Only 20% were familiar with the 2004 standard set by the AABB (formerly the
American Association of Blood Banks) for bacterial testing of all platelet
components.

Even when testing is performed, false-negative results are possible, so
doctors should consider the possibility of bacterial contamination when they
are treating patients who develop fevers in reaction to transfusions, the
MMWR's editors pointed out in a note published with the report.

SOURCE: Morbidity and Mortality Weekly Report CDC Surveillance Summary,
February 25, 2005.


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