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Chronic myelogenous leukemia (CML) is characterized by its hallmark
oncogene BCR-ABL and the progression from a chronic phase toward an acute
leukemia, with a differentiation arrest of the leukemic clone. In the present
study, we conducted a microarray analysis using an inducible model of BCR-ABL
_expression_ based on the TET-OFF system, and we found that osteopontin (OPN), a
component of stem cell niche, is overexpressed in BCR-ABL-expressing
cells.
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