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Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder
characterized by the balanced reciprocal translocation t (9:22). The resulting
fusion gene, the BCR-ABL, is responsible for oncogenesis. Imatinib mesylate is a
novel molecule, which inhibits the protein product of this fusion gene and hence
has been used in the treatment of CML. The present study evaluates 174 patients
with CML treated with imatinib mesylate.
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