Dear Listmembers:
Some good news for CML'ers who do not live close enough to NYC to participate in the CML vaccine trial at Sloan-Kettering (www.mskcc.org)
.
Around or about the end of 2005, the Phase 2 trial will be expanded to MD Anderson, UCLA, and Oregon, according to MSKCC sources. It appears that Dr. Cortes at MDACC and Dr. Druker at OHSU will be involved with the trial. Presumably, Dr. Sawyers will be involved at the UCLA trial, but I have not confirmed this.
I survived the intial trial screening process at MSKCC on Wednesday, having surrendered 14 vials of blood to establish the base-line data to measure my immune response to the vaccine as well as some extra aspirate taken during the bone marrow aspiration. I was told that Dr. David Scheinburg, inventor of the vaccine, will personally receive a sample of the aspirate samples from trial participants.
Present at the screening were my doctor, Dr. Gupta, head of the trial, and Suzanne Chanel, the brilliant clinical trial nurse, who handles the nuts-and-bolts of clinical trials at the hospital.
The official title of the trial, according to the patient informed consent documents I signed is: "PIlot Trial of a Synthetic Tumor Specific Breakpoint Peptide Vaccine in Patients with Chronic Myelogenous Leukemia and Minimal Residual Disease."
You must show Philadelphia Chromosome positive on the RT-PCR to qualify, so if I hit ZERO PCR, I won't qualify. (PCR in February was .00015% on 600 mg. of IM.)
If the PCR results shows positive, I return to MSKCC on Aug. 3 for the first inoculation.
If the PCR result shows negative, I'll jump for joy. Talk about a win-win situation!
I'll provide addtional information about the trial in future posts. Meanwhile, if you are interested in further information on the vaccine there is an article on Jennifer's excellent website detailing the results of an earlier MSKCC trial:
Just go this link and download the article :
You may also contact Dr. Gupta, the trial head, at: (212) 639-2327
email: [EMAIL PROTECTED].
Best regards,
Carl Davies
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