[CML] The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target cell interaction.

[Rob]

To study natural killer (NK) cell mediated antileukemic activity in chronic myelogenous leukemia (CML) we investigated the ability of HLA-matched and mismatched CD56+ cells to inhibit CFU-GM formation by leukemic CD34+ cells. In 14 HLA-identical donor-recipient pairs, donor CD56+ cells inhibited CML CFU-GM comparably to effectors from 14 HLA-mismatched unrelated individuals (mean inhibition 42+/-9% vs 39.5+/-7% at a 10:1 E:T ratio), suggesting that KIR incompatibility was not essential for an anti-leukemic effect. Both CD56+CD3- (NK) and CD56+CD3+(NK-T) cells inhibited CFU-GM growth of CML but not normal CD34+ cells.   http://cmlhope.com/?q=node/76 New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: cml@yahoogroups.com Subscribe:  [EMAIL PROTECTED] Unsubscribe:  [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED]  CML Group Web Site http://groups.yahoo.com/group/CML YAHOO! GROUPS LINKS  Visit your group "CML" on the web.    To unsubscribe from this group, send an email to:  [EMAIL PROTECTED]    Your use of Yahoo! Groups is subject to the Yahoo! Terms of Service.