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Activating mutations in tyrosine kinases have been identified in
hematopoietic and non-hematopoietic malignancies. Recently we and others
identified a single recurrent somatic activating mutation (JAK2V617F) in the
JAK2 tyrosine kinase in the myeloproliferative disorders (MPD) polycythemia
vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. We
used direct sequence analysis to determine if the JAK2V617F mutation was present
in acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML)/atypical
chronic myelogenous leukemia (aCML), myelodysplastic syndrome (MDS), B-lineage
acute lymphoblastic leukemia (ALL), T-cell ALL, and chronic lymphocytic leukemia
(CLL).
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