Hi all... I'm Sherry and my dh (age 37) was dx just 4 months ago with CML - ph+, accelerated phase. He started the "wonder drug" and has not done well with neutropenia and thrombocytopenia. All the same he has dropped form 88% to 28% leukemic cells present in FISH. His second PCR was drawn yesterday.
I'm just wondering if anyone has had the level of intolerance he is experiencing with Gleevec and how low the docs actually dropped the dosage? He started on 600mg, and within 2 weeks platelets were at 15 and neutros at 0.5. Once he recovered, dosage was dropped to 400mg and the same thing happened after 18 days. During his last drug holiday, with plans for one more shot at 300mgs, my husband asked the direct question if 300 causes the same response, can we try 200 and the doc said NO. 200mg would not have an effect on the cancer, so we would then have to discuss moving forward with the bmt (we have a related doner, hooray!). This week, Lorne had to stall the treatment again because of thrombocytopenia and doc wants him to try 200mg once his cbc has recovered. ??????? So which is it - I don't think we are getting all of the info that is being discussed between all of the medical players. They want to try anf build up his tolerance to the drug. I have been doing some research and so far have not found one reference to a dosage of less than 300mg. Not only that, but all I have read indicates that in the accelerated phase, this course of action is not recommended at all. I need to know the rationale behind this new plan and my dh is happy to just follow doctors orders, no questions asked. I need fuel for my fire - so to speak. I can't make him understand that he should be informed of any varying opinions among the medical team and then WE can make an informed decision. Please email me if you have any info to share... thanks Sherry ------------------------ Yahoo! Groups Sponsor --------------------~--> <font face=arial size=-1><a href="http://us.ard.yahoo.com/SIG=12ksfk2dm/M=327951.6903888.7846657.1589681/D=grphealth/S=1705061628:TM/Y=YAHOO/EXP=1124546228/A=2896150/R=0/SIG=11dd2v0rf/*http://www.facetheissue.com/depression.html";>Ever feel sad or cry for no reason at all? Depression. Narrated by Kate Hudson</a>.</font> --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
