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European Rare Diseases Therapeutic Initiative could provide an
important new mechanism for developing new drugs~~~~~~
Pharmaceutical News~~~~~~
Published: Tuesday, 23-Aug-2005~~~~~~
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Because of the very high costs in developing drugs for rare genetic
diseases, and the low return on investment, the pharmaceutical
industry has rarely developed specific treatments for many of these
diseases. But a new public-private partnership, called the European
Rare Diseases Therapeutic Initiative (ERDITI) <http://www.erditi.org>,
could provide an important new mechanism for developing new drugs.  In
an article in this month's open access international medical journal
PLoS Medicine <http://www.plosmedicine.org/>, Alain Fischer, Head of
the Department of Pediatric Immunology at the Necker University
Hospital <http://www.anapath.necker.fr/>, Paris, France, and
colleagues describe how ERDITI is bringing drug companies and academic
researchers together to find new treatments for rare diseases.  "The
thousands of compounds that have been developed by pharmaceutical
companies for more common diseases but that were abandoned or failed
to achieve registration for several reasons (such as biopharmaceutical
properties, toxicity, lack of efficacy, or strategic reasons)
represent a treasure worth exploiting," say the authors.  The idea
behind ERDITI is that participating drug companies give these
"abandoned" compounds to academic researchers who then investigate
whether the compounds might be effective for treating rare diseases.
Companies benefit from this relationship with academia in many ways,
say the authors--for example, by demonstrating corporate social
responsibility. The research on treatments for rare diseases may also
lead to the discovery of drugs for the treatment of more common
diseases, which could be highly profitable to industry.  The ERDITI
partnership between industry and academia, say the authors, is
governed by a charter of collaboration which includes "a standard
agreement that describes the objectives of the research and defines
the framework for the transfer and use of compounds. It also defines
the rights and obligations of each party in terms of protection of
information, intellectual property

, and industrial property."  <http://www.plosmedicine.org/> ~~~~~~


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