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Over the past 30 years, a relatively simple growth factor and its cognate
receptor have provided seminal insights into the understanding of the genetic
basis of cancer, as well as growth factor signalling. The epidermal growth
factor (EGF), its cognate receptor (EGFR) and related family members have been
shown to be important in normal, as well as the malignant growth of many cell
types including: glioblastomata, astrocytomas, medulloblastomata, non-small cell
lung carcinoma (NSCLC) and breast cancer.
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