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Hi to
everyone. I have been so overwhelmed with work the last few weeks.I also
had a chance to travel with my husband for a short vacation.. I want you
to know though that I have been reading all your e-mails and all the
valuable information provided by Nancy on Dr. Bubalo's notes and
others. Congratulation to Cheryl for her 5 th
anniversary.
I Hate to ask
for advice when I've been so lax lately, but I need some opinions. I got
my QPCR results . Counts were higher than the last
test.
My B2A2 is less than 0.001% limit (thanks GOD)
but B3A2 is now 0.045. Last time I had a reading of 0.025% for B3A2. My stubborn
count of B3A2 has been fluctuating between 0.06 and 0.025 for the last 10
months. I am on 400 mg of Gleevec. I will see my doctor in two weeks. Although I
know that this is still a low count but I wonder if any one had the same
situation and had to increase dosage.I think this standard dose is not enough to
kill all leukemia cells and achieve PCRU. Don't take me wrong, I am grateful to
Gleevec/ IM for giving me hope for a better life with
CML.
Love and Peace to you all
Teresa T
dxd 1/03
CCR 7/3
Zero Club# 764
PCRU pending
----- Original Message -----
Sent: Tuesday, October 04, 2005 6:24
AM
Subject: [cml 2] Dr. Bubalo, #2
Dr. Bubalo, #2
Drug Interactions
* cause
reduction of chemotherapeutic effects........
St. John's Wort, garlic,
gingko, grape seed, Kava, nutmeg, quercitin
(partial
list)
*chemotherapy drugs affected............
includes Gleevec,
Taxol, Tamoxifen (partial list, included many
familiar sounding drugs used
with BMT, preconditioning and treatment)
**per Dr. Bubalo, problem with
St. John's Wort, it speeds up
metabolism of Gleevec and it is not as
effective.
____________________
some herbals or supplements
increase the effects of selected
chemotherapy drugs
these
include:
echinacea, ginseng, goldenseal, grapefruit juice/seed extract,
licorice, milk thistle (fruit and seed), red clover, red yeast,
valerian, wild
cherry
____________________
____________________
Effects on Blood
Elements
**may lower platelets
**may affect red blood cell
production
**may increase early types of blood cells
**may increae the
risk of bleeding when used with blood thinning
agents (ie
warfarin/Coudadin)
Agents which may reduce platelet numbers (complete
list given)
*alpha lipoic acid (IV)
*chromium picolinate
*Gingko
biloba (WHO ADR Report)
*kava kava (chronic use)
*L-arginine
(IV)
*Lentinan (shiitake mushroom component)
*parsley (massive amount of
volatile oil)
*pokeweed
*selenium
*ephedra (6 cases with
FDA)......banned substance
Agents which may increase the effects of
blood thinners (complete
list given)
*arnica
*bilberry
*Bishop's
Weed
*borage seed oil
*bromelian
*chamomile
*clove
*coenzyme
Q-10
*danshen
*dexpanthenol
*Devil's Claw
*Dong
Quai
*Fenugreek
*feverfew
*fish oils
*garlic
*ginger
*gingko
biloba
*ginseng
*green tea
*horse chestnut sweet clover
*IP-6
(inositol 6
hexaphosphate)
*licorice
*meadowsweet
*onion
*papain
*parsley
*passion
flower
*quassia
*quinine...........which some of us use for muscle
cramps
*red clover
*Reishi mushroom
*St. John's Wort
*sweet
clover
*tumeric
*Vit E-containing herbs (ie sunflower
seeds)
______________
Agents that may decrease iron
absorption
*black
cohosh
*chamomile
*feverfew
*hawthorn
*gossypol
*nettle
*plantain
*saw
palmetto
*St. John's Wort
*valerian
Take these 2 hours away from
any iron supplements
______________
Increase early forms of blood
cells (may be undesirable)
*alkylglycerols (shark cartilage and shark
liver oil)
*melatonin
__________________
Agents of concern with
surgery
**Stop these agents 2 weeks before surgery
echinacea -
affects liver function
ephedra (Ma huang) - increased cardiac risk
......now banned
garlic, ginkgo, ginseng - affect blood clotting
St.
John's Wort - decreases efficacy of anesthetics
valerian - makes anesthesia
unpredictable
resume them when it is OK with your
surgeon
_____________________
next installment.....herbal safety
issue, regulation of herbal
industry
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Date: 10/5/2005
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