Scientists at The Ohio State University Comprehensive Cancer Center have identified a new pathway in the progression of chronic myelogenous leukemia (CML). They also discovered that an extract from the root of a common ornamental plant can suppress the process.

The findings, appearing in the November issue of Cancer Cell, may yield new treatment options for the estimated 4,600 people in the United States who are expected to develop CML this year – especially those with advanced disease, or those who become resistant to the drug Gleevec.

The promising new extract is forskolin, which comes from the root of the plant coleus forskohlii, a native of India that is used in the United States as an ornamental plant.

Early results on CML patient cells both in culture and in mice showed that forskolin reduced the cancer cells’ ability to grow by up to 90 percent.

 
 


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