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Four case reports of patients with myeloproliferative
syndrome receiving therapy with hydroxycarbamide (synonymous: hydroxyurea) and
developing streaky longitudinal pigmentation appeared in fingernails and
toenails several months after starting this therapy. BACKGROUND: Pigmentation of
finger- and toenails presents a wide range of differential diagnostic
considerations. They can be of infectious, melanocytic or exogenous origin or
caused by metabolic disorders. PATIENTS AND METHODS: Three women and one man,
ranging in age from 62 and 87 years, were treated with hydroxycarbamide for
myeloproliferative syndrome or chronic myelogenous leukemia for five to twelve
years. All four patients were Fitzpatrick skin types II.
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- [CML] [Longitudinal melanonychia induced by hydroxyurea therapy] Rob
