Michael, I also get mouth sores in response to gleevec, although mine is somewhat different than yours. Mine primarily affects the edges of my tongue and the insides of my cheeks. It causes whitened areas under the skin. This side effect has been gradually decreasing with time ( started taking gleevec in April 2005 at 400 mg, increasing to 800 mg in June 2005). The soreness became worse with the dose increase. When it first appeared, I took 2 courses of Diflucan in the event that it was Oral Thrush (an oral yeast infection) which does occur periodically in chemotherapy patients. However, the Diflucan didn't help. Some CML list members gave me some helpful suggestions. I found that using Tom's Natural toothpaste, and using Biotene Dry Mouth mouthwash were helpful to decrease the burning associated with brushing my teeth. I understand that there is something called "magic mouthwash" that can be helpful as a kind of a swish and spit treatment to help numb your mouth a little if you are having trouble eating, however, I can't really vouch for that either way as I didn't try it. Your oncologist or dentist can probably call a prescription for the magic mouthwash in to your phamacist if you want to give it a try. My oncologist didn't know know what about it, but my dentist and pharmacist did. The problem has gradually diminished to the point where it is barely noticeable now. Hang in there, hopefully time will help you too! How long have you been on gleevec? How long have you had the mouth sores? What is your gleevec dosage?
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