I am looking forward to hear from you Cheryl.
Cheryl-Anne Simoneau <[EMAIL PROTECTED]> wrote:
Cheryl-Anne Simoneau <[EMAIL PROTECTED]> wrote:
Hello All,I was reading through the posts and noticed that there are new younger patients here.Some of you might be interested in this abstract that will be presented atASH (American Society of Hematology) this year. I will be going to ASH so, I will be happy to report back.Happy reading!Cheryl-Anne[1104] Conception and Pregnancy in Patients (pts) with Chronic
Myeloid Leukemia (CML) Receiving Therapy with Imatinib Mesylate (IM).
Session Type: Poster Session 262-I
Pat Ault, Hagop Kantarjian, Susan O'Brien, Charles Koller, Stefan
Faderl, Emil J. Freireich, Mary Beth Rios, Jorge Cortes Leukemia,
University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
Although pts with CML receiving IM therapy are required to practice
contraception while on therapy, there are isolated case reports of
conception and pregnancy while on therapy. Here we present our
experience with 18 pts who conceived while on IM therapy: 10 females
and 8 males. All 10 females received IM for chronic phase (CP) CML.
At the time of conception 1 had a complete cytogenetic (CG) response
(CG CR), 3 a partial CG response (CG PR), 2 a minor CG response (CG
MR), 2 complete hematologic response (CHR), and 2 no response. All
pts stopped therapy immediately when pregnancy was recognized. Pts
were managed with hydroxyurea (n=3), leukapheresis (n=1), interferon
(n=1) or observation. Two pts had a spontaneous and 1 an elective
abortion; 7 pregnancies continued uneventfully until delivery (median
duration of pregnancy 36 weeks). Eight babies have been born (1 pair
of twins): one had hypospadias, 7 were normal. The median age of the
children is now 14 months (mo) and all are developing normally. At
the time of delivery/abortion, 5 pts were 100% Ph-positive, 3 had
still a CG MR and 1 a CG PR [i.e. 5 of 7 evaluable had increased Ph
off therapy (1 not tested yet, 2 results pending) (median off therapy
9 months, range 4 to 22 months).] Pts re-started therapy after
delivery and again after a median of 18 months after delivery (range
5 to 48 months), 3 have a CG CR, 2 CG PR, 1 CG MR, 2 CHR and 1
unknown. Among 8 males (6 CP, 2 AP) who impregnated their partners
while on IM, 9 pregnancies resulted in the birth of 8 healthy babies
and 1 spontaneous abortion. One baby had a mild rotation of the small
intestine that resolved surgically. There were no complications of
the other 7 babies. With a median age of 37 mo (range, 5 to 50),
there are no known growth or development problems for any of the
babies. This small experience suggests that conception while
receiving IM is most frequently associated with a normal pregnancy
and healthy babies, provided IM is immediately discontinued. Still,
the recommendation to practice effective contraception while on IM
should be enforced.
Abstract #1104 appears in Blood, Volume 106, issue 11, November 16,
2005
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