Rob:
The CML bcr-abl breakpoint fusion peptide vaccine reported in the Italian study was an earlier version.
The vaccine in trials at MSKCC is a more potent version in which "the peptides have been altered to try to make them more immunogenic," according to an MSKCC research doctor.
I'll know more about the vaccine's effects on me sometime in June when I get a BMA after the 11th, and final, injection.
Best Wishes for a Happy Holiday!
Carl
Rob <[EMAIL PROTECTED]> wrote:
To: [email protected], [email protected], [EMAIL PROTECTED]
From: Rob <[EMAIL PROTECTED]>
Date: Tue, 13 Dec 2005 22:10:28 -0600
Subject: [CML] CML Vaccine Gives Uneven Results in Control of Residual Disease
A vaccine against chronic myelogenous leukemia (CML) has resulted in a molecular response, to varying degrees, in most of the 21 patients treated in ongoing phase II trials.
In a study presented during the 47th annual meeting of the American Society of Hematology that is underway in Atlanta, Georgia, Dr. Monica Bocchia of the University of Siena, Italy, and colleagues reported interim results with CML VAX100, a peptide-based vaccine that targets the bcr-abl genes in CML cells.
Patients in the study had persistent residual disease after maximal response with imatinib therapy had been achieved. Eighteen patients completed the initial immunization schedule of six vaccinations given at two-week intervals. Of these, eight received four booster doses of the vaccine.
http://cmlsupport.blogspot.com/2005/12/cml-vaccine-gives-uneven-results-in.html
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