Guo XQ, Zhang J, Fu X, Wei Q, Lu Y, Li Y, Yin G, Mao Y, Xie Y, Rui Y, Ying K
Front Biosci. 2006 May 1; 11: 1924-31
Camptothecin (CPT) is a potent inhibitor of DNA topoisomerase I with a wide spectrum of anti-tumor activity. Relatively little information is available regarding the relation of known topoisomerase-mediated DNA damage with other intracellular pathways. To gain an insight into the intracellular molecular mechanisms of Topoisomerase I inhibitor camptothecin-mediated DNA damage leading to cell death, we used a high-density cDNA microarray to assess sensitive early gene _expression_ profiles in SGC7901 (gastric cancer), Hela (cervical adenocarcinoma), K562 (chronic myelogenous leukemia) and HL60 (promyelocytic leukemia) tumor cells stimulated with camptothecin for 1 h at the concentrations of GI50 (50 % growth inhibition after 24 h of treatment).
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Posted by Rob to CML Newswire: Medical And Technical News On Chronic Myelogenous Leukemia at 12/23/2005 01:06:04 AM
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