An interesting article . . .  

Barb Heathcote
==============================================


Acetaminophen and Tylenol bottles currently recommend that adults 
take no more than 4,000 milligrams a day, or eight extra-strength 
pills. Doubling that amount is enough to kill, said Dr. Anne Larson 
of the University of Washington Medical Center.  (AP Photo ) 

By LAURAN NEERGAARD AP Medical Writer 
The Associated Press 

WASHINGTON Dec 26, 2005 — Think popping extra pain pills can't hurt? 
Think again: Accidental poisonings from the nation's most popular 
pain reliever seem to be rising, making acetaminophen the leading 
cause of acute liver failure. 

Use it correctly and acetaminophen, best known by the Tylenol brand, 
lives up to its reputation as one of the safest painkillers. It's 
taken by some 100 million people a year, and liver damage occurs in 
only a small fraction of users. 

But it's damage that can kill or require a liver transplant, damage 
that frustrated liver specialists insist should be avoidable. 

 

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The problem comes when people don't follow dosing instructions or 
unwittingly take too much, not realizing acetaminophen is in hundreds 
of products, from the over-the-counter remedies Theraflu and Excedrin 
to the prescription narcotics Vicodin and Percocet. 
"The argument that it's the safest sort of has overruled the idea 
that people cannot take any amount they feel like," says Dr. William 
Lee of the University of Texas Southwestern Medical Center, who 
laments that acetaminophen is popped like M&Ms. 

Acetaminophen bottles currently recommend that adults take no more 
than 4,000 milligrams a day, or eight extra-strength pills. 

Just a doubling of the maximum daily dose can be enough to kill, 
warns Dr. Anne Larson of the University of Washington Medical Center. 

Yet, "if two is good, 10 is better in some patients' minds," she says 
with a sigh. 

The Food and Drug Administration has long wrestled with the liver 
risk, warning two years ago that more than 56,000 emergency-room 
visits a year are due to acetaminophen overdoses and that 100 people 
die annually from unintentionally taking too much. 

A study published this month by Larson and Lee has agency officials 
weighing whether to revisit the issue. 

Over six years, researchers tracked 662 consecutive patients in acute 
liver failure who were treated at 22 transplant centers. (Acute liver 
failure is the most severe type, developing over days, unlike chronic 
liver failure that can simmer for years because of alcohol abuse or 
viral hepatitis.) 






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