The Glivec (imatinib) story begins with 2 Philadelphia researchers: Peter Nowell, MD, of the University of Pennsylvania School of Medicine, and David Hungerford, MD, of the Institute for Cancer Research. They were able to identify a genetic mutation in patients with CML (chronic myeloid leukaemia) in 1960.(1) The 2 researchers found that a section of DNA was missing from chromosome 22. This alteration soon became known as the Philadelphia (Ph) chromosome and could be detected in approximately 95% of patients with CML. The discovery meant that for the first time ever, scientists had discovered a genetic abnormality linked to a specific kind of cancer. The discovery of the link between the Ph chromosome and CML set off an explosion of research into the genetic causes of cancer.
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Posted by Rob to CML Newswire: Medical And Technical News On Chronic Myelogenous Leukemia at 12/29/2005 01:18:56 AM
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