I've scanned the list but can't seem to post the scan so I have typed the document as is. The ??? are where the paper was hole punched. I can not tell you where this information came from originally, only that we were given a photo copy.
????tro human liver microsome, studies show imatinib mesylate to ??? competitive inhibitor of CYP2C9, CYP2D6 and CYP3A4/5, suggesting that it could reduce the clearance of co-administered drugs whose metabolism is dependent on these P450 cytochrome isoenzymes. Studies show that CYP3A4 is the major human p450 enzyme catalyzing the biotransformation of imatinib mesylate, thus co-administration of drugs which are inducers or inhibitors of this enzyme system could decrease or increase blood imatinib mesylate concentrations, respectively. Medications which interfere with CYP3A4/5 should therefore be avoided. These includes the following medications and foods: carbamazepine, phenytoin, Phenobarbital, grapefruit juice, erythromycin, azithromycin, clarithromycin, rifampin and its analogs, fluconazole, ketoconazole, itraconazole, cimetidine, cannabinoids (marijuana or dronabinol), St. John's Wort and the leuketriene inhibitors used in asthma such as zafirleukast and zileuton (See appendix for extended list). In addition, drug interactions in patients receiving prochlorperazine (Compazine) and coumadin are possible. Patients who require prochlorperazine during therapy should be monitored for akathisia. Because of the potential for serious hemorrhage coumadin may not be used. In addition, there has been one fatal hepatotoxic event in an adult taking acetaminophen. Acetaminophen should not be taken in greater that the recommended dose. Blessings Suzanne (Adam's mom) Adam 12 dx'd CML March 04 MUD BMT Feb 05 www.caringbridge.org/canada/adam --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
