Dear Jane,

  If you have side-effects on Gleevec and your doctor recommends
Sprycel (the BMS drug) once it is approved, I think it is possible to
switch to it.  I think the FDA approval will be for patients who are
Gleevec-resistant and Gleevec intolerant.  So, your doctor has to
recommend one drug over the other because of severe side-effects.

  An interesting point is the pricing of Sprycel and whether that will
have any impact on insurance companies.

   Our doctor recommended Gleevec for Roy when it was not approved
first-line so whether you can switch to Sprycel once it is available
commercially will depend on your doctor's recommendation.

I am so glad you are PCRU.  That has eluded Roy but he is in 3-log
reduction.  Friends who have side-effects on Gleevec are thinking of
the BMS drug once it is FDA approved.  I personally know quite a few
BMS trial patients and long-term they report less side-effects on the
BMS drug than they had on Gleevec.

Please keep us posted on what you do.

Best Wishes,
Anjana
caregiver to Roy


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