I don't know anything about psa tests, and their increase after cml diagnosis. However, I am an ovarian cancer survivor and was long before my cml diagnosis. The test for ovarian is a ca-125. I was followed for nine years after ovarian treatment and my ca-125 was always in the normal range. After being on Gleevec for a few months my ca-125 levels began to increase. This brought me much stress as my doctors tried to figure out if I had two cancers. I had many ct scans, much blood work, and a pet scan. The only thing my doctors could find after watching me closely for three years was an increasing ca-125 and slowly increasing fluid retention. I developed ascites and bi-lateral pleural effusions. The docs at MSKCC all agreed that it must be a recurrence of ovarian cancer. I was scheduled for a laparoscopy by a gynecologic oncologist to find the cancer. Well....he looked and looked, and took many tissue samples, and to the surprise of all, there was no gynecologic cancer. Whew! Finally, the team of oncologists concluded that the fluid retention which was most likely caused by Gleevec caused the ca-125 to give a false positive reading. I was taken off Gleevec and switched to Tasigna. Guess what happened? No more fluid retention and the ca-125 is now back within normal ranges!!! What a relief! The Gleevec had also caused me to have extremely low protein levels, which have also now normalized. I guess what I'm trying to say is not to panic if another test comes out high until you have more information. Sometimes one drug can cause reactions that even the doctors don't know about. Nancy in NY **************An Excellent Credit Score is 750. See Yours in Just 2 Easy Steps! (http://pr.atwola.com/promoclk/100126575x1221322948x1201367184/aol?redir=http://www.freecreditreport.com/pm/default.aspx?sc=668072&hmpgID=62&bcd=May ExcfooterNO62)
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