I've noticed the same thing. However, I think it makes sense to change when side effects start affecting quality of life. I spent only 8 months on Gleevec before switching to Sprycel, which I'm still taking 10 months later. While both drugs have their own side effects, I have found the Sprycel to be FAR more tolerable than the Gleevec (even at 400 mg). If you haven't obtained PCRU (I am close, but not there yet), maybe a different drug would make that difference. Although I'm not sure there's much research that shows that PCRU or just consistently low PCRs are really any different in the long term. My onc was certainly not pushing a different drug - I was the one who wanted to change, and he eventually agreed. I just don't see any sense in enduring unnecessary side effects if you can get the same results with a different drug. Just my thought........... Good luck, -janekaye
On Mar 17, 10:15 am, CottonCammy <[email protected]> wrote: > I'm wondering...is it just me or does it seem that more CMLers are > going 'quickly' on to the 2nd and 3rd (4th?)generation drugs? I > understand that some folks have had such horrible side effects and/or > they became Gleevic-resistant but are doctors 'pushing' patients to > these new drugs? > > After 6 1/2 years on Gleevic I have only been undetectable once. That > was after Dr. Soiffer at Dana Farber increased my dose from 400 to > 600mg. The side effects were HORRIBLE. Right back down to the > 400mg...my counts fluctuate but stay consistently within range. He is > happy with it and my side-effects are tolerable. > > I'm VERY curious as to this... -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope To unsubscribe from this group, send email to cmlhope+unsubscribegooglegroups.com or reply to this email with the words "REMOVE ME" as the subject.
