My husband takes 50 mgs per day.  He started on 70 mgs but had a bout
of pleural effusion and took a 2 week holiday from any drugs and then
went back on Sprycel at 50 mgs per day.  This method was advised by
Dr. Cortes at MD Anderson. He also suffers from a connective tissue
disoder so it is hard to tell if the stabbing pains in his upper back/
shoulder are related to Sprycel or to the fact that he is trying to
come down on prednisone.  The connective tissue disorder (UCTD) was
diagnosed years before the CML.  He also suffers from neuropothy -
again possibly related to his connective tissue issues but the
neuropothy has worsened. Hope this answers your question.

On Aug 16, 4:48 pm, [email protected] wrote:
> Hi Beth, I was started on 150 mgs but was soon put down to 100.  I am  
> tolerating good and went into remission for the first time in just a few 
> months  
> on Sprycel.  There are no bad side effects at least not for me.   Headaches
> and some rash.
> Good luck,
> Jeanie<3
>
> In a message dated 8/11/2010 6:29:23 P.M. Pacific Daylight Time,  
>
> [email protected] writes:
>
> Jeanie,
>
> what dose are you on of sprycel??? one prson here does 40 mgs a day,  
> another 70, others 100 or 140....they want to start me on 100....I am nervous 
>  
> because I have been so sensitive to the knase inhibitors...Beth
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