The product package information shows that paracetamol should not be taken with Glivic/Gleevec. You can find more information through a Google search as well. Pat in Phoenix Some medicines and Glivec may interfere with each other. These include many medicines that are eliminated from the body through the liver: St. John's wort, a herbal medicine found in many products that you can buy without a prescription paracetamol, a medicine found in many common pain relievers and cold remedies (e.g. PanadolR, PanadeineR, CodralR, TylenolR) antibiotic medicines such as rifampicin, ketoconazole, erythromycin, clarithromycin, itraconazole antiviral medicines used to treat HIV/AIDS dexamethasone, a steroid medicine medicines for high cholesterol, such as simvastatin medicines used to treat epilepsy, such as phenytoin, carbamazepine, phenobarbitone warfarin, a medicine used to prevent blood clots some medicines used to treat mental disorders and depression some medicines used to treat high blood pressure and heart problems cyclosporin You may need to take different amounts of these medicines or you may need to take different medicines. Your doctor and pharmacist have more information. If you have not told your doctor about any of these things, tell him/her before you start taking this medicine. _____
From: [email protected] [mailto:[email protected]] On Behalf Of pjgeary Sent: Sunday, October 03, 2010 3:57 PM To: [email protected] Subject: [CMLHope] Anyone aware that Glivic and Panadol pain tablets taken together will create extensive Liver damage Anyone aware that Glivic and Panadol; or paracetimol pain tablets taken together will create extensive Liver damage Any data, I am being advised by my Pharmacists to stop immediately as their syatems are red carding this Any news anywhere _____ From: [email protected] [mailto:[email protected]] On Behalf Of [email protected] Sent: Sunday, October 03, 2010 11:17 PM To: Digest Recipients Subject: [CMLHope] Digest for [email protected] - 1 Message in 1 Topic Today's Topic Summary Group: http://groups.google.com/group/cmlhope/topics * Optimum Sprycel dose <> [1 Update] Topic: Optimum Sprycel dose <http://groups.google.com/group/cmlhope/t/607e18111b280f04> peg <[email protected]> Oct 02 01:18PM -0700 ^ <> Okay... for Beth and those waiting for the outcome of my meeting with the doc that did Sprycel developemental research...here it is: 100mg IS the recommended dose. Does he have patients on less?... Yes...and here is his criteria for reducing the dose: 1. Side effects (he says all side effects on this drug are reversible with reduction or discontinuation)...or...2. Zero achieved and maintained on PCR...verified at least once with BMB. In regard to starting at a lower dose and "tapering" up to 100mg, he said he does not understand why MD's would want to advise their patients to do this, and cautioned against it. He understands that the thought is that it gives the body a chance to "adjust" however, he feels that it also gives the chromosomes a chance to become resistant and could result in Sprycel not being effective. Sort of the same way that taking less of an antibiotic than you would need to overcome an infection allows the infection to become resistant to the antibiotic. For those who are changing from Gleevec because of serious GI side effects and are concerned that Sprycel might be the same... he said that Gleevec is well recognized as the cause of severe gastritis and severe diarrhea in many folks. While there have been some incidents of Colitis with Sprycel, not many, and generally speaking most folks will not have any serious GI side effects on Sprycel. However, a break between the two is recommended to allow GI irritation from Gleevec to settle before introducing Sprycel. In regard to pain medications for headache, etc.... Contrary to popular belief, with Sprycel, Tylenol is OKAY! However, Aspirin, Ibuprofen, Advil, Motrin, Aleve, Naproxin Sodium, or narcotics containing any of these ARE NOT OKAY. They can thin the blood too much when combined with Sprycel. Caution must be taken when adding any med to Sprycel that can thin the blood. In my case, I do occassionally use Celebrex, which can cause the same problem, however, he said it is probably okay as long as my platelets are normal and I only use it occassionally. He believes that current research will soon produce something better than the current TKI's but for now both 2nd gen TKI's, Tasigna and Sprycel, are stronger than Gleevec and should produce better results at supressing CML in more people. Hope sharing this is helpful to you. Keep the faith! peg -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope __________ Information from ESET NOD32 Antivirus, version of virus signature database 5500 (20101003) __________ The message was checked by ESET NOD32 Antivirus. http://www.eset.com -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope
