Hi Jeanie, You are welcome and....I take a beta blocker...Acebutolol 200mg, once daily. It is NOT contraindicated with Sprycel, and according to what I could find, neither is Bystolic. The only problem I have is Sprycel does drop my blood pressure, and so does Acebutolol. So I take the Sprycel in the morning and the beta blocker at bedtime. peg
On Oct 8, 1:01 pm, [email protected] wrote: > Hi Peg and thanks so much. I started on 150 megs because they couldn't > get my platelets and WBC down even after I blood apherisis. I stayed on the > 150 for about 2 months until my counts were going down too low. I was then > put on 100 mgs. I am in PCRU and it was proved by BMA but my onc still > won't let me lower the dose. > Thanks again this was great! My doctor wants me to take Bystolic a beta > blocker. Do any of you take a beta blocker? > Thanks > Jeanie<3 > > In a message dated 10/2/2010 1:19:05 P.M. Pacific Daylight Time, > > [email protected] writes: > > Okay... for Beth and those waiting for the outcome of my meeting with > the doc that did Sprycel developemental research...here it is: > > 100mg IS the recommended dose. Does he have patients on less?... > Yes...and here is his criteria for reducing the dose: > > 1. Side effects (he says all side effects on this drug are reversible > with reduction or discontinuation)...or...2. Zero achieved and > maintained on PCR...verified at least once with BMB. > > In regard to starting at a lower dose and "tapering" up to 100mg, he > said he does not understand why MD's would want to advise their > patients to do this, and cautioned against it. He understands that > the thought is that it gives the body a chance to "adjust" however, he > feels that it also gives the chromosomes a chance to become resistant > and could result in Sprycel not being effective. Sort of the same way > that taking less of an antibiotic than you would need to overcome an > infection allows the infection to become resistant to the antibiotic. > > For those who are changing from Gleevec because of serious GI side > effects and are concerned that Sprycel might be the same... he said > that Gleevec is well recognized as the cause of severe gastritis and > severe diarrhea in many folks. While there have been some incidents of > Colitis with Sprycel, not many, and generally speaking most folks will > not have any serious GI side effects on Sprycel. However, a break > between the two is recommended to allow GI irritation from Gleevec to > settle before introducing Sprycel. > > In regard to pain medications for headache, etc.... Contrary to > popular belief, with Sprycel, Tylenol is OKAY! However, Aspirin, > Ibuprofen, Advil, Motrin, Aleve, Naproxin Sodium, or narcotics > containing any of these ARE NOT OKAY. They can thin the blood too > much when combined with Sprycel. Caution must be taken when adding > any med to Sprycel that can thin the blood. In my case, I do > occassionally use Celebrex, which can cause the same problem, however, > he said it is probably okay as long as my platelets are normal and I > only use it occassionally. > > He believes that current research will soon produce something better > than the current TKI's but for now both 2nd gen TKI's, Tasigna and > Sprycel, are stronger than Gleevec and should produce better results > at supressing CML in more people. > > Hope sharing this is helpful to you. > > Keep the faith! > peg > > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at http://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope
