Hi all, This is my first post here. I have had CML for a bit over 4 years now. I took gleevec for the first 2 and tasigna since. My pcr has been low for about 3 years now (about 2.5 log decrease), but never undetectable. Once in the past I had a pcr rise on a single measurement that then went down again on the next test. I have had this again in my most recent test. The rise was not large and the pcr value is still low in absolute terms. My onc wants to test again in 6 weeks. As you might guess, I am pretty nervous. My question is, has anyone else ever had an increase in their pcr after years of treatment? If so, was it temporary or did it signal treatment resistance? Just trying to get a sense for how frequently fluctuations occur. Thanks for any input. Thanks, Daniel
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