Gleevec was the drug that qualified me dental care with the VA. I have broken teeth, root canals that resulted in brittle shells that broke off at the gums. Richard H. On Sunday, February 3, 2013 1:56:55 AM UTC-6, wa2yyx wrote:
> I did some research and here is what I found out about what to avoid while > taking Gleevec. Please remember that I have never been on any TKI's because > I had a bone marrow transplant many years ago. I just do a lot of research. > > Hopefully this will be able to help you, and others as well. > > Gleevec Interactions > GLEEVEC IS METABOLIZED IN THE LIVER BY CYP3A4. This is the basis > for most interactions, if CYP3A4 is affected by other drugs or foods. A > pharmacist can use computer programs available to pharmacists to check > whether other drugs would interact with Gleevec. > The NCCN Task Force Report on GIST Management includes a table of Gleevec > interactions on pages S12-S13. Download > the pdf at the above link to read this. This table does not name every > possible interaction. > The Gleevec prescribing information from Novartis also details some > interactions. Go to Gleevec.com and click "prescribing information" at > the top of the screen. > ________________________________ > > > GRAPEFRUIT, POMEGRANATE, OTHER CITRUS FRUIT > Due to the metabolism of Gleevec, Novartis recommends that grapefruit and > grapefruit juice be avoided by patients taking Gleevec. > The new NCCN Task Force Report mentions grapefruit juice and > names a quantity of 200-250 ml as increasing blood levels of Gleevec. > That is over 3/4 cup of juice. A smaller quantity might not raise > Gleevec levels much. > Grapefruit juice INHIBITS the liver enzyme (CYP3A4) that > processes Gleevec. If you eat a lot of grapefruit then Gleevec stays in > your blood LONGER. It does not decrease the effectiveness of Gleevec, > as it raises the blood levels of Gleevec. This could potentially > increase side effects. However, if you have no trouble with side > effects, then it would not seem that popping the occasional strawberry, > grapefruit section, or 1/4 cup of pomegranate juice would hurt... > Tangelos are a hybrid of grapefruit and mandarin orange: Some > doctors say to stay away from Tangelos. There have been several > studies, one being the USDA Agricultural Research Service, "....have so > far shown that unlike grapefruit, interactions with STATINS are not > likely with tangelos, even though it is derived from a grapefruit > crossed with a tangerine. This is apparently because the furocoumarins > in grapefruit are not expressed in tangelo. " > > http://www.ars.usda.gov/research/publications/publications.htm?seq_no_115=175058 > > POMEGRANATE juice also affects CYP3A, but not in exactly the same way as > grapefruit. For some medical papers discussing pomegranate > efects on drug disposition see this PubMed search. > ________________________________ > > ST. JOHN'S WORT > ON THE OTHER HAND, St. John's wort does the opposite, increasing > enzyme activity to get Gleevec out of the body faster. Therefore, it is a > clear no-no since it decreases blood levels of Gleevec, thereby > decreasing the drug's effectiveness. > ________________________________ > > STATIN DRUGS > Gleevec raises the level of statins in the blood. Patients who take > statins with Gleevec need to be very cautious, as very serious side > effects such as muscle damage (rhabdomyolysis) may result from excess > statins. Statin dose should be reduced when taking Gleevec. Discuss > this with your pharmacist and doctors. > ________________________________ > > MILK THISTLE > Caution! Milk thistle decreases the activity of CYP3A4, which is the major > enzyme responsible for the metabolism of Gleevec and Sutent. DO > NOT take milk thistle while on these drugs and check with your doctor if > on other drugs. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/groups/opt_out.
