In a message dated 9/7/2014 8:35:11 A.M. Eastern Daylight Time, [email protected] writes:
Effect of a proton pump inhibitor on the pharmacokinetics of imatinib. _Egorin MJ_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Egorin%20MJ[Author]&cauthor=true&cauthor_uid=19740393) 1, _Shah DD_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Shah%20DD[Author]&cauthor=true&cauthor_uid=19740393) , _Christner SM_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Christner%20SM[Author]&cauthor=true&cauthor_uid=19740393) , _Yerk MA_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Yerk%20MA[Author]&cauthor=true&cauthor_uid=19740393) , _Komazec KA_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Komazec%20KA[Author]&cauthor=true&cauthor_uid=19740393) , _Appleman LR_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Appleman%20LR[Author]&cauthor=true&cauthor_uid=19740393) , _Redner RL_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Redner%20RL[Author]&cauthor=true&ca uthor_uid=19740393) , _Miller BM_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Miller%20BM[Author]&cauthor=true&cauthor_uid=19740393) , _Beumer JH_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Beumer%20JH[Author]&cauthor=true&cauthor_ uid=19740393) . _Author information_ (http://www.ncbi.nlm.nih.gov/pubmed/19740393#) Abstract AIMS: Imatinib mesylate (Gleevec/Glivec), which has revolutionized the treatment of chronic myeloid leukemias (CML) and gastrointestinal stromal tumours (GIST), has been reported to cause gastric upset. Consequently, proton pump inhibitors (PPI) are frequently co-administered with imatinib. Because PPI can elevate gastric pH and delay gastric emptying or antagonize ATP-binding-cassette transporters, they could influence imatinib absorption and pharmacokinetics. We aimed to evaluate whether use of omeprazole has a significant effect on imatinib pharmacokinetics. METHODS: Twelve healthy subjects were enrolled in a two-period, open-label, single-institution, randomized cross-over, fixed-schedule study. In one period, each subject received 400 mg imatinib orally. In the other period, 40 mg omeprazole (Prilosec) was administered orally for 5 days, and on day 5 it was administered 15 min before 400 mg imatinib. Plasma concentrations of imatinib and its active N-desmethyl metabolite CGP74588 were assayed by LC-MS, and data were analyzed non-compartmentally. RESULTS: PPI administration did not significantly affect the imatinib area under the plasma concentration vs time curve (AUC) (34.1 microg ml(-1) h alone vs 33.1 microg ml(-1) h with omeprazole, P= 0.64; 80% power), maximum plasma concentration (C(max)) (2.04 microg ml(-1) alone vs 2.02 microg ml(-1) with omeprazole, P= 0.97), or half-life (13.4 h alone vs 14.1 h with omeprazole, P= 0.13). CONCLUSIONS: Our results indicate that the use of omeprazole does not significantly affect the pharmacokinetics of imatinib, as opposed to, for example, dasatinib where PPI decreased AUC and C(max) two-fold. Don't know when this study was done, but it seems Gleevec is different than Sprycel. I was on Gleevec for 5 years, and I do think it affects the stomach. I was on the proton pump inhibitor while in the hospital but when I went on Sprycel, the leaflet said no, so I quit them. They never seemed to help me anyway. Great study, Blessings Jeanie<3 In a message dated 9/5/2014 9:54:31 A.M. Eastern Daylight Time, [email protected] writes: And I'm on Gleevec Sent on the new Sprint Network from my Samsung Galaxy S®4. -------- Original message -------- From: [email protected] Date:09/05/2014 8:48 AM (GMT-05:00) To: [email protected] Subject: proton pump inhibitors That is so strange; you aren't supposed to be taking those proton pump inhibitors at all at least that's what is says on my Sprycel leaflet; Check you leaflet for drug not to take with your meds. Blessings, Jeanie<3 In a message dated 9/1/2014 10:58:06 A.M. Eastern Daylight Time, [email protected] writes: Silent reflux just means I have no symptoms...no heartburn BUT experience hoarseness and other symptoms. Dr. Druker asked me to try prilosec. I did and was off it in two days...the muscle spasms were worse than the Gleevec spasms...never imagined anything worse...but it was. ..up all night except for 3 hours of sleep. I wrote Dr. Druker after reading about side effects on the internet. He then wanted me to try Nexium...told him I'm done being a guinea pig...would try diet eating alone Hugs, Susan Sent on the new Sprint Network from my Samsung Galaxy S®4. -------- Original message -------- From: [email protected] Date:09/01/2014 10:53 AM (GMT-05:00) To: [email protected] Subject: Re: Jaw pain, etc Hi Susan and so sorry to hear about your reflux. Be careful about proton pump inhibitors as you are not supposed to be on those when on your TKIs as least that is what my Sprycel booklet states. It says you can take antiacids 2 hours before or 2 hours after your meds. This is things like Tums. No, no hoarseness, but my ear fills full and my jaw hurts at the point of the hinge. What is silent reflux? Thanks, Blessings, Jeanie<3 In a message dated 9/1/2014 9:03:08 A.M. Eastern Daylight Time, [email protected] writes: Jeannie: I was just self diagnosed with silent reflux...have had it a long time. Do you have hoarseness, too? Anyway, you might wNt to ask your doctor or ENT. Hugs, Susan Rosenthal Sent from my iPad -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
