Analysis of the Developing Heart Monday, January 14, 2013 - 4:00pm KEC 1001
Cindy Grimm Research Associate Professor Mechanical Engineering Oregon State University Abstract The developing heart is a complex feedback system where the shape of the heart affects the strains and stresses that the tissue experience, which helps to drive the developmental changes, which in turn changes the shape of the heart. Leading contributors to congenital heart defects have been shown to be environmental conditions, such as smoking and obesity, which alter blood flow characteristics. In this research we aim to understand the link between changes in the environment (and hence blood flow) and the resulting effect on heart development through the mechanism of strains and stresses felt by tissues. Specifically, we image the in-vivo developing chick heart cardiac cycle using OCT imaging; from this we extract 3D surfaces of the developing heart at approximately 190 points in the cardiac cycle. We then analyze these surfaces to determine how placing a band around the developing heart alters the cardiac cycle. In this talk I will focus on the latter half of this analysis (creating consistent, temporally varying surfaces) and a variety of visualization approaches we have developed in order to understand, and quantify, the complex motion of the beating heart. Joint work with Dr. Sandra Rugonyi, Oregon Health and Science University. Speaker Biography Dr. Cindy Grimm works in the area of surface modeling and visualization, with an emphasis on biomedical applications. Her current projects include: modeling the developing heart, understanding how the shape of bat ears influences their sonar patterns, 3D sketching, and interfaces for 3D medical image segmentation. She received her PhD from Brown University in 1995 in the area of surface modeling, spent two years working at Microsoft Research on facial animation, then ten years as faculty in Computer Science and Engineering at Washington University in St. Louis.
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