A fully funded PhD Studentship is available to work with Dr Anna Lobley,
Associate Director, Biological Data Science at Exscientia, Dr Arkaitz
Zubiaga, Senior Lecturer at the School of Electronic Engineering and
Computer Science, Queen Mary University London, and Dr Claudia Cabrera,
Lecturer in Bioinformatics at the William Harvey Research Institute at
Queen Mary University London.
Awards will cover UK tuition fees, stipend at UKRI rate (currently
£19,668), and a consumable allowance for 4 years (pro-rata for part-time
applicants).
*Project Description:*
Methods for automated target and biomarker identification typically
involve ranking genes and proteins according to indication relevance
criteria. A typical process then involves traversing scientific
literature for supporting evidence. However, many age-related western
world diseases bear the hallmarks of complex heterogeneous conditions
that vary along a spectrum of disease severity. They frequently involve
multiple systems and pathways. Hence selection pools comprise many
hundreds to thousands of genes. Selecting the best targets and
stratification biomarkers from a large candidate pool presents a
significant challenge in drug discovery. Current approaches are at best
semi-automated or rely on expert opinion. This means it is difficult to
avoid bias in such decision making tasks. Decision theory is one branch
of Artificial Intelligence that can be applied to help resolve these
complexities. Automated reasoning and argumentation theory are two
appropriate branches of natural language processing well suited to the
task. The aim of this project is to fully automate target and biomarker
selections using a combination of NLP-based and recommendation methods.
The end goal is to generate unbiased decisions from a complex network of
information relationships.
We are seeking a highly motivated students who are passionate about
contributing to biological knowledge through the application of NLP to
large text corpora and biomolecular data sets.
The deadline for applications is May 1st 2023 and projects start in
September 2023.
For more details, see
https://www.findaphd.com/phds/project/target-biomarker-selection-using-systems-networks-decision-theory-and-nlp/?p157258
For more on eligibility and how to apply, see
https://www.qmul.ac.uk/deri/ukri-aidd-doctoral-training-programme/apply/
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