Link: 
https://med.ucsd.edu/_files/post-docs/UCSD%20Postdoc%20Computer%20Scientist%20JD.pdf

The position is for a postdoctoral fellowship to join an innovative, 
multi-disciplinary research team
funded by a prestigious NIH Director’s Avant-Garde Award 
(https://today.ucsd.edu/story/uc-san-
diego-researcher-wins-5.6m-nih-avant-garde-award-to-prevent-hiv-hepatitis-c-and-overdose).
 Dr.
Natasha Martin (https://profiles.ucsd.edu/natasha.martin) leads the project, 
with additional
mentorship from faculty specializing in biostatistics, infectious diseases, and 
epidemiology. The
project aims to revolutionize HIV and hepatitis C virus (HCV) prevention and 
resource allocation
for people who use drugs (PWUD) across the United States. The project will 
pioneer the integration
of large language models (LLMs) to create behavioral "digital twins," embedded 
within dynamic
epidemic and economic simulation models to guide real-world public health 
policy.

The Division of Infectious Diseases and Global Public Health (IDGPH) at UCSD is 
in the
Department of Medicine in the School of Medicine of the University of 
California San Diego
(https://idgph.ucsd.edu/). IDGPH is a multidisciplinary center that includes 
faculty, postdocs, and
graduate students from Epidemiology, Social Sciences, Biostatistics, Medicine, 
and other
disciplines. IDGPH aims to eliminate the burdens of infectious diseases and 
health disparities by
delivering outstanding patient care, conducting world-class multidisciplinary 
health research,
directing the institutional response to antimicrobial resistance, preventable 
healthcare associated
infections, and emerging pathogens, and offering leadership, consultation and 
training on global
public health, equity, microbiology, and infectious diseases topics.

Position Title: Postdoctoral Fellow

Duties and Responsibilities: The postdoctoral fellow will develop, fine-tune, 
and evaluate large
language model–based methods to predict the preferences and likely choices of 
people who use
drugs regarding HIV, hepatitis C, overdose prevention, and substance use 
services. Using mixed
qualitative and quantitative participant data, the fellow will create and 
validate individual-level
behavioral “digital twins” that can generate realistic responses to questions 
about intervention
preferences, such as willingness to use long-acting injectable pre-exposure 
prophylaxis, hepatitis C
testing and treatment services, naloxone, syringe services, or medications for 
opioid use disorder.
Responsibilities will include data preparation and integration, prompt design 
and model adaptation,
development of reproducible computational pipelines, and rigorous evaluation of 
predictive
accuracy, calibration, reliability, and performance across participant 
subgroups. The fellow will
work closely with an interdisciplinary team spanning artificial intelligence, 
biostatistics,
epidemiology, infectious diseases, and substance use research, contribute to 
manuscripts and
conference presentations, and help advance responsible and transparent 
applications of LLMs in
research involving people who use drugs.

Position Qualifications: Candidates should have a doctoral degree in computer 
science,
biostatistics, epidemiology, or a related field. Strong computational skills 
and expertise in either AI
or machine learning. Start date and term are negotiable.

Position Instructions: Applicants should submit a cover letter, CV, and contact 
information for
three references to Matthew Rivera ([email protected]).
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